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陈笑艳研究组
陈笑艳课题组简介

  

  课题组现有工作人员10名,其中研究员1名、教授级高级工程师1名,副研究员1名、助理研究员4名;博士研究生4名,硕士生3名。

    

  

  药物代谢活化过程与药物不良反应机理研究;手性药物立体选择性药动学和代谢机理研究;药动学生物样品分析技术研究;创新药物开发过程的药物代谢和动力学研究。

 

 

    

  在药物代谢活化研究方面,近年来重点阐述了二氢异喹啉类生物碱醌型反应性代谢中间体的生成机理以及与肺毒性的相关性;发现了吡咯里西啶生物碱新的代谢活化途径;从代谢活化角度,揭示了几种中药注射剂不良反应的发生机制。阐明了多沙唑嗪、普罗帕酮、昂当司琼、吗啉硝唑等手性药物在人体内的立体选择性药动学和代谢机理。在创新药物药代动力学研究方面,重点在体内微量药物及代谢产物分析新技术、放射性色谱-质谱追踪和鉴定代谢产物、药物吸收以及转运等领域开展了系列研究工作。近5年来,发表SCI收录期刊论文50篇。承担和参与多项国家和上海市的重大基础科学研究项目。

    

  
  1. Jin H, Li L, Zhong DF, Liu J, Chen XY*, Jiang Zheng*. Pulmonary toxicity and metabolic activation of tetrandrine in CD-1 Mice. Chem Res Toxicol, 2011, DOI: 10.1021/tx200290s.
  2. Chen MX, Liu K, Zhong DF, Chen XY*. Trimethylsilyldiazomethane derivatization coupled with solid-phase extraction for the determination of alendronate in human plasma by LC-MS/MS. Anal Bioanal Chem, 2011, DOI: 10.1007/s00216-011-5467-4.
  3. Xie C, Yu K, Zhong DF, Yuan T, Ye F, Jarrell J, Millar A, Chen XY*. Investigation of isomeric transformations of chlorogenic acid in buffers and biological matrices by ultraperformance liquid chromatography coupled with hybrid quadrupole/ion mobility/orthogonal acceleration time-of-flight mass spectrometry. J Agric Food Chem, 2011, 59: 11078-11087
  4. Xie C, Yang SL, Zhong DF, Dai XJ, Chen XY*. Simultaneous determination of dronedarone and its active metabolite debutyldronedarone in human plasma by liquid chromatography–tandem mass spectrometry: Application to a pharmacokinetic study. J Chromatogr B, 2011, 879: 3071-3075
  5. Deng P, Zhong DF, Nan FJ, Liu S, Li D, Yuan T, Chen XY*, Zheng J*. Evidence for the bioactivation of 4-nonyphenol to quinine methide and ortho-benzoquinone metabolites in human liver microsomes. Chem Res Toxicol, 2010, 23: 1617-1628
  6. Liu K, Zhong DF, Chen XY*. Enantioselective determination of doxazosin in human plasma by liquid chromatography-tandem mass spectrometry using ovomucoid chiral stationary phase. J Chromatogr B, 2010, 878: 2415-2420
  7. Liu K, Zhong DF, Zou HY, Chen XY*. Determination of tegafur, 5-fluorouracil, gimeracil and oxonic acid in human plasma using liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal, 2010, 52: 550-556
  8. Liu K, Zhong DF, Chen XY*. Enantioselective quantification of chiral drugs in human plasma with LC–MS/MS. Bioanalysis, 2009, 1: 561-576
  9. Wang YY, Zhong DF, Chen XY*, Zheng J*. Identification of quinone methide metabolites of dauricine in human liver microsomes and in rat bile. Chem Res Toxicol, 2009, 22: 824-834
  10. Liu K, Dai XJ, Deng P, Ma JF, Zhong DF, Chen XY*. Simultaneous determination of 6R-leucovorin, 6S-leucovorin and 5-methyltetrahydrofolate in human plasma using chiral liquid chromatography-tandem mass spectrometry. J Chromatogr B, 2009, 877: 902-910
  11. Zhang HC, Zhong DF, Zhang ZZ, Dai XJ, Chen XY*. Liquid chromatography/tandem mass spectrometry method for the quantification of deserpidine in human plasma: Application to a pharmacokinetic study. J Chromatogr B, 2009, 877: 3221-3225
  12. Deng P, Zhong DF, Chen XY*. Determination of tropisetron in human plasma by liquid chromatography–tandem mass spectrometry. J Pharm Biomed Anal, 2009, 49: 848-852
  13. Liu K, Dai XJ, Zhong DF, Chen XY*. Quantitative determination of ondansetron in human plasma by enantioselective liquid chromatography-tandem mass spectrometry. J Chromatogr B, 2008, 864: 129-136
  14. Duan XT, Zhong DF, Chen XY*. Derivatization of beta-dicarbonyl compound with 2,4-dinitrophenylhydrazine to enhance mass spectrometric detection: Application in quantitative analysis of houttuynin in human plasma. J Mass Spectrom, 2008, 43: 814-824
  15. Zhong S, Zhong DF, Chen XY*. Improved and simplified liquid chromatography/ electrospray ionization mass spectrometry method for the analysis of underivatized glucosamine in human plasma. J Chromatogr B, 2007, 854: 291-298
  16.   Gao J, Zhong DF, Duan XT, Chen XY*. Liquid chromatography/negative ion electrospray tandem mass spectrometry method for the quantification of rosuvastatin in human plasma: Application to a pharmacokinetic study. J Chromatogr B, 2007, 856: 35-40
  17.   Chen XY, Deng P, Dai XJ, Zhong DF. Simultaneous determination of amodiaquine and its active metabolite in human blood by ion-pair liquid chromatography-tandem mass spectrometry. J Chromatogr B, 2007, 860: 18-25
  18.   Chen XY, Duan XT, Dai XJ, Zhong DF Development and validation of a liquid chromatographic/ tandem mass spectrometric method for the determination of sertraline in human plasma. Rapid Commun Mass Spectrom, 2006, 20: 2483-2489
  19.   Chen XY, Liu D, Luan Y, Zhong DF. Determination of zolmitriptan in human plasma by liquid chromatography-tandem mass spectrometry method: Application to a pharmacokinetic study. J Chromatogr B, 2006, 832: 30-35.
  20.   Chen XY, Cui L, Duan XT, Zhong DF. Pharmacokinetics and metabolism of the flavonoid scutellarin in humans after a single oral administration. Drug Metab Dispos, 2006, 34: 1345-1352.

  

  用于代谢产物研究的UPLC-Q/TOF MS、Q-Trap MS、在线放射性检测器和半制备HPLC系统;用于药动学生物样品定量分析的LC-MS/MS系统;用于放射示踪定量分析的液体闪烁计数仪和氧化燃烧仪。

    

 

 
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