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李亚平研究组
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李亚平研究组
李亚平研究组简介

 

   课题组现有研究员、副研究员、高级工程师、助理研究员和博士/硕士研究生(含联合培养的博士/硕士研究生)30余人, 包括国家重大科学研究计划(973)首席科学家, 国家杰出青年科学基金获得者, 中科院青年促进会会员,上海市领军人才和优秀学术带头人,上海市科技启明星等。

 

 

  基于纳米技术的药物靶向输送;核酸药物非病毒载体及其导入系统;药物新剂型与新制剂的研究开发。

 

 

 

  在抗癌药物靶向输送系统的应用基础研究方面取得了一系列重要进展,设计、构建了多种用于抗肿瘤转移或降低肿瘤耐药性,提高化疗药物疗效或降低其毒副作用的新型纳米输送系统,以及提高核酸药物转染效率的新型非病毒载体,并对其特性和作用机制进行了深入系统研究;采用制剂技术提高了一批难溶性药物和侯选药物的溶解度与口服吸收等; 迄今在Nat Med, Adv Mater, ACS Nano, Adv Drug Deliv Rev, Adv Funct Mater, Nanotoxicology,Small, Biomaterials, Nanomedicine NBM, J Control Release, Mol Pharmaceut, Biomacromolecule等国际重要学术期刊上发表SCI论文100余篇; 在新药研究方面, 已获得新药证书9 项,临床批件5项(创新药物临床批件4项), 已报 SFDA 的新药3 项;申请专利50余项(授权20项);3名博士生获中国科学院优秀博士论文(2012,2011,2010),1名博士生获全国百篇优博论文提名(2011).

 

  

     

 

  1. Yu Chen, Pengfei Xu, Hangrong Chen*, Yongsheng Li, Wenbo Bu, Zhu Shu, Yaping Li*, Jiamin Zhang, Lingxia Zhang, Limin Pan, Xiangzhi Cui, Zile Hua, Jin Wang, Linlin Zhang and Jianlin Shi*. Colloidal HPMO NPs: silica-etching chemistry tailoring, topological transformation and nano-biomedical applications.Adv Mater 25(2013):3100-5
  2. Qi Yin, Jianan Shen, Zhiwen Zhang, Haijun Yu, Yaping Li*. Reversal of multidrug resistant by stimuli-responsive drug delivery systems for therapy of tumor. Adv Drug Deliv Rev. (2013, Online)
  3. Xiaopin Duan, Jisheng Xiao, Qi Yin, Zhiwen Zhang, Haijun Yu, Shirui Mao,Yaping Li*. Smart pH-Sensitive and Temporal-Controlled Polymeric Micelles for Effective Combination Therapy of Doxorubicin and Disulfiram. ACS Nano (2013, Online)
  4. Xiaopin Duan, Yaping Li*. Physicochemical characteristics of nanoparticles affect circulation, biodistribution, cellular internalization and trafficking. Small9 (2013):1521-32
  5. Jisheng Xiao, Xiaopin Duan, Qi Yin, Zehong Miao*, Haijun Yu, Chunying Chen, Zhiwen Zhang*, Jun Wang, Yaping Li*. The inhibition of metastasis and growth of breast cancer by blocking the NF-κB signaling pathway using bioreducible PEI-based/p65 shRNA complex nanoparticles. Biomaterials34 (2013):5381-90
  6. Haijun Yu, Yonglong Zou, Lei Jiang, Qi Yin, Xinyu He, Lingli Chen, Zhiwen Zhang,Wangwen Gu, Yaping Li* Induction of apoptosis in non-small cell lung cancer by downregulation of MDM2 using pH-responsive PMPC-b-PDPA/siRNA complex nanoparticles Biomaterials 34 (2013):2738-47
  7. Zhiwen Zhang, Li Ma, Shijun Jiang, Zeying Liu, Jian Huang, Lingli Chen, Yaping Li*. A self-assembled nanocarrier loading teniposide improves the oral delivery and drug concentration in tumor. J Control Release166(2013):30-37
  8. Jianan Shen, Huiping Sun, Pengfei Xu, Qi Yin, Zhiwen Zhang, Siling Wang, Haijun Yu, Yaping Li*. Simultaneous inhibition of metastasis and growth of breast cancer by co-delivery of twist shRNA and paclitaxel using pluronic P85-PEI/TPGS complex nanoparticles. Biomaterials. 34 (2013) 1581-1590
  9. Jianan Shen, Qi Yin, Lingli Chen, Zhiwen Zhang, Yaping Li*. Co-delivery of paclitaxel and survivin shRNA by pluronic P85-PEI/TPGS complex nanoparticles to overcome drug resistance in lung cancer. Biomaterials33 (2012):8613-8624
  10. Yu Chen, Qi Yin, Xiufeng Ji, Shengjian Zhang, Hangrong Chen, Yuanyi Zheng, Yang Sun, Haiyun Qu, Zheng Wang, Yaping Li*, Xia Wang, Kun Zhang, Linlin Zhang, Jianlin Shi*. Manganese oxide-based multifunctionalized mesoporous silica nanoparticles for pH-responsive MRI, ultrasonography and circumvention of MDR in cancer cells.Biomaterials33 (2012) 7126-7137
  11. Qi Yin, Jianan Shen, Lingli Chen, Zhiwen Zhang, Wangwen Gu, Yaping Li*. Overcoming multidrug resistance by co-delivery of mdr-1 and survivin-targeting RNA with reduction-responsible cationic poly(β-amino esters). Biomaterials33 (2012) 6495-6506
  12. Yu Chen, Yu Gao, Hangrong Chen*, Deping Zeng, Yaping Li* Yuanyi Zheng, Faqi Li, Xiufeng Ji, Xia Wang, Feng Chen, Qianjun He, Linlin Zhang, Jianlin Shi*. Engineering inorganic nanoemulsions/nanoliposomes by fluoride-Silica chemistry for efficient delivery/co-delivery of hydrophobic agents. Adv Funct Mater 8 (2012) 1586–1597
  13. Pengcheng Zhang, Luojuan Hu, Qi Yin, Linyin Feng*, Yaping Li*. Transferrin-conjugated polyphosphoester hybrid micelle loading paclitaxel for brain-targeting delivery: synthesis, preparation and in vivo evaluation. J Control Release159(2012)429-434
  14. Ge Zhang*, Baosheng Guo, Heng Wu, Tao Tang, Bao-Ting Zhang, Lizhen Zheng, Yixin He, Zhijun Yang, Xiaohua Pan, Heelum Chow, Kinwah To, Yaping Li, Dahu Li, Xinluan Wang, Yixiang Wang, Kwongman Lee, Zhibo Hou, Nan Dong, Gang Li, Kwoksui Leung, Leungkim Hung, Fuchu He, Lingqiang Zhang & Ling Qin*. A delivery system targeting bone formation surfaces to facilitate RNAi-based anabolic therapy. Nat Medicine 18 (2012) 307-314
  15. Qianjun He, Zhiwen Zhang, Fang Gao, Yaping Li*, Jianlin Shi*. In vivo biodistribution and urinary excretion of mesoporous silica nanoparticles: effects of particle Size and PEGylation.Small 7(2011)271-280
  16. Fang Gao, Zhiwen Zhang, Huihui Bu,Yan Huang, Zhiwei Gao, Jianan Shen, Chunjie Zhao, Yaping Li*. Nanoemulsion improves the oral absorption of candesartan cilexetil in rats: performance and mechanism. J Control Release 149 (2011)168-174
  17. Yu Gao, Lingli Chen, Zhiwen Zhang, Yi Chen, Yaping Li*. Reversal of multidrug resistance by reduction-sensitive linear cationic click polymer/iMDR1-pDNA complex nanoparticles. Biomaterials 32(2011)1738-1747
  18. Qi Yin, Yu Gao, Zhiwen Zhang, Pengchen Zhang, Yaping Li*.Bioreducible poly (β-amino esters)/shRNA complex nanoparticles for efficient RNA delivery. J Control Release 151(2011) 35-44
  19. Yu Gao, Rongfu Yang, Zhiwen Zhang, Lingli Chen, Zuyue Sun, Yaping Li*.Solid lipid nanoparticles reduce systemic toxicity of docetaxel: performance and mechanism in animal. Nanotoxicology5 (2011)636-49
  20. Yu Gao, Yu Chen,Xiufeng Ji, Xinyu He,Qi Yin, Zhiwen Zhang, Jianlin Shi* and Yaping Li*. Controlled intracellular release of doxorubicin in multidrug resistant cancer cells by tuning the shell-pore sizes of mesoporous silica nanoparticles. ACS Nano 5 (2011):9788-9798

 

 

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