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药物制剂研究中心
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李亚平研究组
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黄永焯研究组
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黄永焯研究组
黄永焯研究组

 

  副研究员:杨永新

  博士后:王慧媛

  技术员:叶俊晓

  研究生:王诏、刘金华、郭倩倩、姜一帆、陈应之

  

  

 

  

  1. 经皮新剂型与新技术:包括化学药物/中药有效成分经皮新剂型与新技术,经皮疫苗给药研究。
  2. 生物技术药物输送系统研究:包括生物材料的合成,新型给药系统的设计与制备,载体与大分子药物的相互作用,载体给药系统与生物屏障的相互作用,生物大分子黏膜给药研究,以及大分子药物靶向给药研究。

 

  配备有较为齐备的现代药物制剂及给药系统研究设施,主要包括:全自动溶出仪、透皮扩散仪、高效液相色谱仪、快速蛋白液体色谱、热重分析仪、荧光光度计、多功能酶标仪、冷冻干燥器、真空干燥机、冷冻离心机,以及细胞培养设备。

 

   近三年研究论文: 

 

  1. Y Wang, EG Liu, XY Sun, P Huang, H Long, H Wang, YZ Huang*. Pluronic L61 as a long-circulating modifier for enhanced liposomal delivery of cancer drugs, Polymer Chemistry, 2013, online, DOI: 10.1039/C3PY00042G
  2. YZ Huang*, YF Jiang, HY Wang, JX Wang, HN He, V Yang*. Curb Challenges of the "Trojan Horse" Approach: Smart Strategies in Achieving Effective yet SafeCell-penetrating Peptide-based Drug Delivery, Advanced Drug Delivery Reviews, 2013, online. DOI: 10.1016/j.addr.2012.11.007
  3. L Yan, HY Wang, YF Jiang, JH Liu, Z Wang, YX Yang, SW Huang, YZ Huang*. Cell-penetrating Peptide-modified PLGA Nanoparticles for Enhanced Nose-to-brain Macromolecular Delivery, Macromolecular Research, 2013, online, DOI: 10.1007/s13233-013-1029-2
  4. HN He, A David, B Chertok, A Cole, K Lee, J Zhang, JX Wang, YZ Huang, V Yang*. Magnetic Nanoparticles for Tumor Imaging and Therapy: A So-called Theranostic System. Pharmaceutical Research, 2013, online. DOI: 10.1007/s11095-013-0982-y
  5. YJ Sun, WB Dong, HY Wang, YZ Huang*, HK Gu, V Yang*, J Gong*. Template Synthesis of PMAA@Chitosan Hollow Nanorods for Docetaxel Delivery. Polymer Chemistry. 2013, 4, 2489-2495
  6. JH Liu, YX Zhao, Q Guo, Z Wang, HY Wang, YX Yang, YZ Huang*, TAT-modified Nanosilver for Combating Multidrug-resistant Cancer. Biomaterials, 2012, 33(26),6155-6161
  7. M Shen, YZ Huang, LM Hana, J Qin, V Yang, JX Wang*. Multidisciplinary drug delivery system for targeting tumor and its acidic microenvironment. Journal of Controlled Release. 2012, 161(3), 884-892
  8. YS Park, A David, YZ Huang, J Park, HN He, Y Byun, V Yang*. In vivo delivery of cell permeable antisense-HIF1a-oligonucleotide to adipose tissue reduces adiposity in obese mice. Journal of Controlled Release. 2012, 161(1), 1-9
  9. YX Yang, YF Jiang, Z Wang, JH Liu, L Yan, JX Ye, YZ Huang*. Skin-permeable Quaternary Nanoparticles with Layer-by-layer Structure Enabling Improved Gene Delivery. Journal of Material Chemistry, 2012, 22, 10029-10034
  10. JX Wang, YZ Huang, A David, B Chertok, L Zhang, FQ Yu, V Yang*. Magnetic nanoparticles for brain tumors imaging. Current Pharmaceutical Biotechnology. 2012, 13(12), 2403-2416
  11. S Wang, H Wang, WQ Liang*, YZ Huang*. An Injectable Hybrid Nanoparticle-in-Oil-in-Water Submicron Emulsion for Improved Delivery of Poorly Soluble Drugs. Nanoscale Research Letters, 2012, 7, 219
  12. SY Dong, S Wang, CH Zheng, WQ Liang*, YZ Huang*. An in situ-forming, solid lipid/PLGA hybrid implant for long-acting antipsychotics. Soft Matter, 2012, 7(12), 5873-5878
  13. YX Yang, Y Gao, LL Chen, YZ Huang*, YP Li*. Downregulation of survivin expression and enhanced chemosensitivity of MCF-7 cells to adriamycin by PDMAE/survivin shRNA complex nanoparticles. International Journal of Pharmaceutics. 2011, 405(1), 186-195
  14. YZ Huang, YF Rao, JL Chen, V Yang*, WQ Liang. Polysorbate cationic synthetic vesicle for gene delivery. Journal of Biomedical Materials Research - Part A. 2011, 96A(3), 513-519
  15. HN He, A David, J Zhang, YS Park, JX Wang, YZ Huang, JK Wang, V Yang. Low molecular weight protamine/insulin formulation with potential to attenuate protamine-masqueraded insulin allergy. Macromolecular Research, 2011, 19(12), 1224-1226
  16. YZ Huang, YS Park, C Moon, A David, HS Chung, V Yang*. Synthetic skin-permeable proteins enabling needleless immunization. Angewandte Chemie International Edition, 2010, 49(15), 2724-2727,
  17. YZ Huang, FQ Yu, YS Park, JX Wang, MC Shin, HS Chung, V Yang*. Co-administration of protein drugs with gold nanoparticles to enable percutaneous delivery. Biomaterials. 2010, 31(34), 9086-9091,
  18. FQ Yu, L Zhang, YZ Huang, A David, V Yang*, The magnetophoretic mobility and superparamagnetism of core-shell iron oxide nanoparticles with dual targeting and imaging functionality. Biomaterials. 2010, 31(22), 5842-5848,
  19. YS Park, YZ Huang, YJ Park, A David, L White, HN He, HS Chung, V Yang*. Specific down regulation of 3T3-L1 adipocyte differentiation by cell-permeable antisense HIF1á-oligonucleotide. Journal of Controlled Release. 2010, 144(1), 82-90,
  20. XL Zheng, YZ Huang, CH Zheng*, SY Dong, WQ Liang. Alginate-Chitosan-PLGA composite microspheres enabling single-shot hepatitis B vaccination. The AAPS Journal. 2010, 12 (4), 519-524,
  21. YZ Huang, YS Park, JX Wang, C Moon, YM Kwon, HS Chung, V Yang*. ATTEMPTS system: a macromolecular prodrug strategy for cancer drug delivery. Current Pharmaceutical Design. 2010, 16 (21), 2369-2376

 

 

  承担课题情况

  1.国家自然科学基金重大研究计划(91029743 )(主持)

  2.国家自然科学基金面上项目(81172996 )(主持)

  3.上海市浦江人才计划(主持)

  4.复旦大学智能化递药教育部及全军重点实验室开放课题(主持)

  5. 中国博士后基金面上项目(一等) (王慧媛博士))

  

  

 
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合影3   实验室
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