近五年来课题组在J Neurosci, J Cell Sci, Mol. Pharmacol, Biochem J, J Neurochem, J Pharmacol Exp Ther 和Cell Research等国际杂志上发表SCI论文20多篇。研究成果并被Nature系列杂志Nature China选为研究亮点加以报道。已获得国家国际发明专利1项和国家发明专利2项。申请国家发明专利3项。
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Liu Y, Zhou QX, Hou YY, Lu B, Yu C, Chen J, Ling QL, Cao J, Chi ZQ, Xu L*, Liu JG* (2012) Actin polymerization-dependent increase in synaptic Arc/Arg3.1 expression in the amygdala is crucial for the expression of aversive memory associated with drug withdrawal. J Neurosci 32: 12005-12017.
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Wang WS, Kang S, Liu WT, Li M, Liu Y, Yu C, Chen J, Zhi-Qiang Ch ZQ, He L, and Jing-Gen Liu JG* (2012) Extinction of aversive memories associated with morphine withdrawal requires ERK-mediated epigenetic regulation of brain-derived neurotrophic factor transcription in the rat ventromedial prefrontal cortex. J Neurosci 32: 13763-13775.
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Lu G, Zhou QX, Kang S, Li QL, Zhao LC, Chen JD, Sun JF, Cao J, Wang YJ, Chen J, Chen XY, Zhong DF, Chi ZQ, Xu L*, Liu JG* (2010) Chronic morphine treatment impaired hippocampal LTP and spatial memory via accumulation of extracellular adenosine acting on adenosine A1 receptors. J Neurosci 30: 5058-5070.
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Xu C, Hong MH, Zhang LS, Hou YY, Wang FF, Chen YJ, Xu XJ, Chen J, Xie X, Ma L, Chi ZQ, Liu JG* (2010) Serine 363 Residue of δ-Opioid Receptor is Crucial for Adopting Distinct Pathways to Activate ERK1/2. J Cell Sci 123:4259-4270.
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Hou YY, Lu B, Li M, Liu Y, Chen J, Chi ZQ, and Liu JG* (2009) Involvement of actin rearrangements within the amygdala and the dorsal hippocampus in aversive memories of drug withdrawal in acute morphine dependent rats. J Neurosci 29: 12244-12254.
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Wang YJ, Tao YM, Xu XJ, Chen J, Cao YL, Chi ZQ, Liu JG* (2009) Pharmacological Characterization of ATPM-AZ, a Novel Mixed κ Agonist and μ Agonist/Antagonist That Attenuates Morphine Antinociceptive Tolerance and Heroin Self-Administration Behavior. J Pharmacol.Exp Ther 329: 306-313.
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Hong MH, Xu C, Wang YJ, Ji JL, Tao YM, Xu XJ, Chen J, Xie X, Zhi-Qiang Chi ZQ, Liu JG* (2009) Role of Src in Ligand-specific Regulation of δ-opioid Receptor Desensitization and Internalization. J Neurochem 108: 102-114.
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Chen XL, Lu G, Gonh YX, Zhao LC, Chen J, Chi ZQ, Yang YM, Chen Z, Li QL, Chi ZQ, Liu JG* (2007) Involvement of changes in protein expression of hippocampal energy metabolism enzymes in behavioral abnormalities during chronic morphine treatments. Cell Research 17: 689-700.
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Lin X, Li Q, Wang YJ, Ju YW, Chi ZQ, Wang MW, Liu JG* (2007) Morphine Inhibits Doxorubicin-induced Reactive Oxygen Species Generation and Nuclear Factor-κB Transcriptional Activation in Neuroblastoma SH-SY5Y Cells. Biochem J 406: 215-221.
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Wu ZQ, Chen J, Chi ZQ and Liu JG* (2007) Involvement of Dopamine System in Regulation of Na+,K+-ATPase in the Striatum upon Activation of Opioid Receptors by Morphine. Mol Pharmacol 71: 519-530.
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Wu ZQ, Li M, Chen J, Chi ZQ and Liu JG* (2006) Involvement of cAMP/cAMP-Dependent Protein Kinase Signaling Pathway in Regulation of Na+,K+-ATPase upon Activation of Opioid Receptors by Morphine. Mol Pharmacol 69: 866-876.
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Liu JG, Anand KJS (2001) Protein kinases modulate the cellular adaptations associated with opioid tolerance and dependence. Brain Research Reviews 38: 1-19.
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Liu JG, Ruckle MB, Prather PL (2001) Constitutively active μ-opioid receptors inhibits adenylyl cyclase activity in intact cells and activates G-proteins differently than the agonist DAMGO. J Biol Chem 276: 37779-37786.
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Liu JG, Prather PL (2001) Chronic exposure to μ-opioid agonists produces constitutive activation of μ-opioid receptors in direct proportion to the efficacy of the agonist used for pretreatment. Mol Pharmacol 60: 53-62.
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Liu JG, Prather PL (2002) Chronic agonist treatment converts antagonists into inverse agonists at delta-opioid receptors. J Pharmacol Exp Ther 302: 1070-1079.
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