课题组有研究员1人，博士后2人，研究助理4人，研究生及联合培养研究生6人。

离子通道和受体是重要的膜蛋白，不仅发挥重要的生理功能，也是主要的药物作用靶点。我们综合电生理学、药理学和结构生物学等技术手段，研究受体与离子通道的调控机制，开展钾通道的结构与功能研究。最近针对抑郁症等神经系统疾病，我们进一步开展了动物行为学和在体电生理学研究，从天然产物中筛选和发现新的抗抑郁药物；同时“以药效测机制”开展药理学机制研究。

1. Zhang X, Wang J, Feng Y, Ge J, Li W, Sun W, Iscla I, Yu J, Blount P, Li Y*, Yang M*.Structure and molecular mechanism of an anion-selective mechanosensitive channel of small conductance.Proc Natl Acad Sci U S A. 2012 Oct 16. [online]  
2. Ning Shia,1, Weizong Zenga,1, Sheng Yeb, Yang Li^c* and Youxing Jianga*. Crucial Points within the Pore as Determinants of K+ Channel Conductance and Gating，JOURNAL OF MOLECULAR BIOLOGY, 411(1), pp 27-35, 2011/8/5.
3. Derebe MG,Zeng W,Li Y,Alam A,Jiang Y. Structural studies of ion permeation and 　Ca2+ blockage of a bacterial channel mimicking the cyclic nucleotide-gated channel pore.  PANS.2011 Jan 11;108(2):592-7.
4. Sheng Ye1, Yang Li²& Youxing Jiang3,4　Novel insights into K+ selectivity from high-resolution structures of an open K+ channel pore. Nature structural & molecular biology2010,Vol.17,1019-1023
5. Li Y, Berke I, Chen L, Jiang Y. Gating and inward rectifying properties of the MthK K+ channel with and without the gaing ring.J. Gen. Physiol. 2007 Feb;129(2):109-20. 
6. Ye S, Li Y, Chen L, Jiang Y. Crystal Structures of a Ligand-free MthK Gating Ring: Insights into the Ligand Gating Mechanism of K+ Channels.Cell. 2006 Sep 21; 126(6): 1161-1173 
7. Gamper N, Zaika O, Li Y, Martin P, Hernandez CC, Perez MR, Wang AY, Jaffe DB, Shapiro MS. Oxidative modification of M-type K(+) channels as a mechanism of cytoprotective neuronal silencing. EMBO J. 2006 Oct 18;25(20):4996-5004.
8. Li Y, Gamper N, Hilgemann DW, Shapiro MS. Regulation of Kv7 (KCNQ) K+ channel open probability by phosphatidylinositol 4,5-bisphosphate.J. Neurosci. 2005 Oct 26;25(43):9825-35. 
9. Gamper N, Li Y, Shapiro MS. Structural requirements for differential sensitivity of KCNQ K+ channels to modulation by Ca2+/calmodulin.Mol Biol Cell. 2005 Aug;16(8):3538-51. 
10. Li Y, Langlais P, Gamper N, Liu F, Shapiro MS. Dual phosphorylations underlie modulation of unitary KCNQ K+ channels by Src tyrosine kinase.J. Biol. Chem. 2004 Oct 29;279(44):45399-407. 
11. Li Y, Gamper N, Shapiro MS. Single-channel analysis of KCNQ K+ channels reveals the mechanism of augmentation by a cysteine-modifying reagent.J. Neurosci. 2004 Jun 2;24(22):5079-90. 
12. Liu, H.; Li, Y.; Song, M.; Tan, X.; Cheng, F.; Zheng, S.; Shen, J.; Luo, X.; Ji, R.; Yue, J.; Hu, G.; Jiang, H.; Chen, K. Structure-based discovery of potassium channel blockers from natural products: virtual screening and electrophysiological assay testing.  Chem. Biol. 2003, 10, 1103-1113.
13. Liu H, Gao ZB, Yao Z, Zheng S, Li Y, Zhu W, Tan X, Luo X, Shen J, Chen K, Hu GY, Jiang H. Discovering potassium channel blockers from synthetic compound database by using structure-based virtual screening in conjunction with electrophysiological assay. J. Med .Chem. 2007 Jan 11;50(1):83-93. 
14. Yang Li, Guo-Yuan Hu. Huperzine A, a nootropic agent, inhibits fast transient potassium current in rat dissociated hippocampal neurons.Neuroscience Letters 324(20 02) 25–28
15. Yang Li, Guo-Yuan Hu Huperzine A inhibits the sustained potassium current in rat dissociated hippocampal neurons.Neuroscience Letters 329 (2002) 153–156

研究室组织结构

冯林音课题组/刘景根课题组/章海燕课题组/李扬课题组