课题组现有1名研究员，3名研究助理和8名研究生。

金黄色葡萄球菌和绿脓杆菌致病性及耐药性的分子机理；抗细菌感染新靶标的发现和功能确证；针对新靶标的小分子活性化合物的发现。

近三年主要科研成果(* 通讯作者)

1. Deng X, Weerapana E, Ulanovskaya O, Sun F, Liang H, Ji Q, Ye Y, Fu Y, Zhou L, Li J, Zhang H, Wang C, Alvarez S, Hicks LM, Lan L, Wu M, Cravatt BF*, He C*. Proteome-wide Quantification and Characterization of Oxidation-Sensitive Cysteines in Pathogenic Bacteria.Cell Host & Microbe. 2013, 13(3):358-70.
2. Ji Q, Zhang L, Jones MB, Sun F, Deng X, Liang H, Cho H, Brugarolas P, Gao YN, Peterson SN, Lan L, Bae T, He C*. Molecular mechanism of quinone signaling mediated through S-quinonization of a YodB family repressor QsrR.Proc Natl Acad Sci U S A. 2013, 110(13):5010-5.
3. Liu X, Sun X, Wu Y, Xie C, Zhang W, Wang D, Chen X, Qu D, Gan J, Chen H, Jiang H, Lan L*, Yang CG*. Oxidation-sensing regulator AbfR regulates oxidative stress responses, bacterial aggregation, and biofilm formation in Staphylococcus epidermidis.J Biol Chem.2013, 288(6):3739-52.
4. Sun F, Ding Y, Ji Q, Liang Z, Deng X, Wong CC, Yi C, Zhang L, Xie S, Alvarez S, Hicks LM, Luo C, Jiang H, Lan L*, He C*. Protein cysteine phosphorylation of SarA/MgrA family transcriptional regulators mediates bacterial virulence and antibiotic resistance.Proc Natl Acad Sci U S A. 2012, 109(38):15461-6.
5. Deng X, Sun F, Ji Q, Liang H, Missiakas D, Lan L, He C*. Expression of multidrug resistance efflux pump gene norA is iron responsive in Staphylococcus aureus.J Bacteriol.2012, 194(7):1753-62.
6. Zhang J, Ye F, Lan L, Jiang H, Luo C*, Yang CG*. Structural switching ofStaphylococcus aureusClp protease: a key to understanding protease dynamics.J Biol Chem.2011, 286(43):37590-601.
7. Liang Z, Li L, Wang Y, Chen L, Kong X, Hong Y, Lan L, Zheng M, Guang-Yang C, Liu H, Shen X, Luo C*, Li KK*, Chen K, Jiang H*. Molecular basis of NDM-1, a new antibiotic resistance determinant.PLoS One. 2011, 6(8):e23606.
8. Deng X, Lan L, Xiao Y, Kennelly M, Zhou JM, Tang X*. Pseudomonas syringae two-component response regulator RhpR regulates promoters carrying an inverted repeat element.Mol Plant Microbe Interact. 2010, 23(7):927-39.
9. Lan L, Cheng A, Dunman PM, Missiakas D, He C*. Golden pigment production and virulence gene expression are affected by metabolisms in Staphylococcus aureus.J Bacteriol.2010, 192(12):3068-77.
10. Lan L, Murray TS, Kazmierczak BI, He C*.Pseudomonas aeruginosaOspR is an oxidative stress sensing regulator that affects pigment production, antibiotic resistance and dissemination during infection.Mol Microbiol.2010, 75(1):76-91.　

生物安全2级实验室；分子生物学常用仪器、设备。

课题组		waters e2695 HPLC