代表性论著(‡并列第一)
1.Zhong-Qiang Guo‡, Tong Zheng‡,Baoen Chen‡, Cheng Luo‡, Sisheng Ouyang‡, Shouzhe Gong, Jiafei Li, Liu-Liang Mao, Fulin Lian, Yong Yang, Yue Huang, Li Li, Jing Lu, Bidong Zhang, Luming Zhou, Hong Ding, Zhiwei Gao, Liqun Zhou, Guoqiang Li, Ran Zhou, Ke Chen, Jingqiu Liu, Yi Wen, Likun Gong, Yuwen Ke, Shang-Dong Yang, Xiao-Bo Qiu, Naixia Zhang, Jin Ren, Dafang Zhong,Cai-Guang Yang*, Jiang Liu*, Hualiang Jiang*. “Small-molecule targeting of E3 ligase adaptor SPOP in kidney cancer”,Cancer Cell,2016,30, 474-484.
2.Tengfeng Ni‡, Fei Ye‡, Xing Liu‡, Jie Zhang‡, Hongchuan Liu, Jiahui Li, Yingyi Zhang, Yinqiang Sun, Meining Wang, Cheng Luo, Hualiang Jiang, Lefu Lan, Jianhua Gan, Ao Zhang, Hu Zhou,Cai-Guang Yang*, “Characterization of Gain-of-Function Mutant Provides New Insights into ClpP Structure”,ACS Chem. Biol.,2016,11, 1964-1972.
3.Qi Li, Xichun Liu, Yue Huang,Jiafei Li,Jianhua Gan, HaoChen,Cai-Guang Yang*. “Rhein Inhibits AlkB Repair Enzymes and Sensitizes Cells to Methylated DNA Damage”,J. Biol. Chem.2016,291, 11083-11093.
4.Tianlu Wang‡, Tingting Hong‡, Yue Huang‡, Haomiao Su, Fan Wu, Yi Chen, Lai Wei, Wei Huang, Xiaoluan Hua, Yu Xia, Jinglei Xu, Jianhua Gan, Bifeng Yuan, Yuqi Feng, Xiaolian Zhang, Cai-Guang Yang*, Xiang Zhou*, “Fluorescein derivatives as bifunctional molecules for the simultaneous inhibiting and labeling of FTO protein”, J. Am. Chem. Soc.2015, 137,13736-13739.
5.Yue Huang‡, Jingli Yan‡, Qi Li, Jiafei Li, Shouzhe Gong, Hu Zhou, Jianhua Gan, Hualiang Jiang, Gui-Fang Jia*, Cheng Luo*, andCai-Guang Yang*.“Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5”,Nucleic Acids Res.2015,43, 373-384.
6.Jie Zhang‡, Hongchuan Liu‡, Kongkai Zhu‡, Shouzhe Gong, Shaynoor Dramsi, Ya-Ting Wang, Jiafei Li, Feifei Chen, Ruihan Zhang, Lu Zhou, Lefu Lan, Hualiang Jiang, Olaf Schneewind*, Cheng Luo*, Cai-Guang Yang*. “Antiinfective therapy with a small molecule inhibitor of Staphylococcus aureus sortase”,Proc. Natl. Acad. Sci. USA.2014,111,13517-13522.
7.Yue Ding, Xing Liu, Feifei Chen, Hongxia Di, Bin Xu, Lu Zhou, Xin Deng, Min Wu, Cai-Guang Yang*, Lefu Lan*,“A metabolic sensor governing bacterial virulence in Staphylococcus aureus”,Proc. Natl. Acad. Sci. USA,2014,111, E4981-E4990.
8.CHEN BaoEn, GAN JianHua*, YANG CaiGuang*. “The complex structures of ALKBH2 mutants cross-linked to dsDNA reveal the conformational swing of β-hairpin”, Sci. China Chem.2014,57, 307-313.
9.Xing Liu, Xiaoxu Sun, Youcong Wu, Cen Xie, Wenru Zhang, Dan Wang, Xiaoyan Chen, Di Qu, Jianhua Gan, Hao Chen, Hualiang Jiang, Lefu Lan*,Cai-Guang Yang*. “Oxidation-sensing Regulator AbfR Regulates Oxidative Stress Responses, Bacterial Aggregation, and Biofilm Formation in Staphylococcus epidermidis”,J. Biol. Chem.2013,288, 3739-3752.
10.Fei Ye‡, Jie Zhang‡,Hongchuan Liu, Rolf Hilgenfeld, Ruihan Zhang, Xiangqian Kong, Lianchun Li, Junyan Lu, Xinlei Zhang, Donghai Li, Hualiang Jiang*,Cai-Guang Yang*, Cheng Luo*.“Helix Unfolding/refolding Characterizes the Functional Dynamics of Staphylococcus aureus Clp Protease”,J. Biol. Chem.2013, 288, 17643-17653.
11.Chengqi Yi, Baoen Chen, Bo Qi, Wen Zhang, Guifang Jia, Liang Zhang, Charles Q. Li, Aaron R. Dinner, Cai-Guang Yang*, Chuan He*. “Duplex Interrogation by a Direct DNA Repair Protein in the Search of Damage”,Nat. Struct. Mol. Biol.2012,19, 671-676.
12.Baoen Chen‡, Fei Ye‡, Lu Yu‡, Guifang Jia, Xiaotian Huang, Xueju Zhang, Shuying Peng, Kai Chen, Meining Wang, Shouze Gong, Ruihan Zhang, Jinya Yin, Haiyan Li, Yiming Yang, Hong Liu, Jiwen Zhang, Haiyan Zhang, Ao Zhang, Hualiang Jiang, Cheng Luo* and Cai-Guang Yang*. “Development of Cell-active N6-Methyladenosine RNA Demethylase FTO Inhibitor”,J. Am. Chem. Soc.2012,134, 17963-17971.
13.Jing Deng‡, Ning Li‡, Hongchuan Liu‡, Zhili Zuo‡, Ai Ow Liew, Weijun Xu, Gang Chen, Xian Kun Tong, Wei Tang*, Jin Zhu, Jianping Zuo, Hualiang Jiang, Cai-Guang Yang*, Jian Li*, Weiliang Zhu*. “Discovery of Novel Small Molecule Inhibitors of Dengue Viral NS2B-NS3 Protease Using Virtual Screening and Scaffold Hopping”,J. Med. Chem.2012,55, 6278-6293.
14.Jie Zhang‡, Fei Ye‡, Lefu Lan, Hualiang Jiang, Cheng Luo*, Cai-Guang Yang*. “Structural Switches of Staphylococcus aureus Clp Protease: a key to understanding protease dynamics”J. Biol. Chem.2011,286, 37590-37601.
15.Chun-Xiao Song, Yao Sun, Qing Dai, Xing-Yu Lu, Miao Yu,Cai-Guang Yang*, Chuan He*. “Detection of 5-Hydroxymethylcytosine in DNA by Transferring a Keto-glucose by Using T4 Phageb-glucosyltransferase”ChemBioChem2011,12, 1682-1685.
16. Hao Chen*, Chengqi Yi, Jin Zhang, Wenru Zhang, Zhiyun Ge, Cai-Guang Yang*, Chuan He*. “Structural Insight into the Oxidation-sensing Mechanism of the Antibiotic Resistance of Regulator MexR”EMBO Rep.2010,11, 685-690.
17.Baoen Chen, Hongchuan Liu, Xiaoxu Sun, Cai-Guang Yang*.“Mechanistic Insight into the Recognition of Single-stranded and Double-stranded DNA Substrates by ABH2 and ABH3”Mol. BioSyst.2010,6, 2143-2149.
18.《化学生物学学科前沿与展望》,第26章抗菌药物作用靶标发现及其先导化合物设计,科学出版社,647–675页,2013年。
19.《中国学科发展战略·化学生物学》,第10章化学合成生物学,科学出版社,272–290页, 2015年。
实验室装备分子生物学、蛋白质表达纯化、蛋白质晶体学、细胞生物学以及有机合成化学的基本仪器设备。
在研课题:
1、国家自然科学基金国际合作与交流项目,81661138004,FBLD技术平台在抗菌新药研究中的应用,2016/07-2019/06,主持。
2、国家自然科学基金面上项目,21672234,m1A去甲基化酶ALKBH3的小分子调控研究,2017/01-2020/12,主持。
3、国家重点研发计划“蛋白质机器与生命过程调控”重点专项,2016YFA0501500,信号转导过程中蛋白质机器的活细胞标记与在体调控,2016/07-2021/06,参加。
4、973项目,2015CB910603,RNA表观遗传对DNA损伤修复调控机制,2015/01-2019/12,参加。
5、国家自然科学基金面上项目,21372237,RNA去甲基化酶的作用机制和抑制剂研究,2014/01-2017/12,主持。