课题组现有成员31名，其中在职工作人员5名、（研究员1名，副研究员1名，助理研究员1名，助理实验师2名），博士后4名、在读博士生7名、在读硕士生5名、在读联合培养研究生10名，是一支与国内外学术交流广泛，思维活跃，综合素质和科研创新能力强大的科研队伍。

主要从事药物化学基础和应用基础的研究工作，研究领域涉及药物化学、有机合成和计算机辅助药物设计等学科。

1. Jiang Wang, Shengbin Zhou, Daizong Lin, Xiao Ding, Hualiang Jiang, and Hong Liu*Highly Diastereo- and Enantioselective Synthesis of syn-β-Substituted Tryptophans via the Reaction of a Chiral Equivalent of Nucleophilic Glycine and Sulfonylindoles. Chem.Comm. 2011,47, 8355-8357.
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3. Xu Zhang, Yu Zhou, Hengshuai Wang, Diliang Guo, Deju Ye, Yungen Xu, Hualiang Jiang,a and Hong Liu.* An Effective Synthetic Entry to Fused Benzimidazoles via Iodocyclization. Advanced Synthesis & Catalysis. 2011, 353, 1429-1437.
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5. Haifeng Sun, He Huang, Dengyou Zhang, Enguang Feng, Wangke Qian, Lei Zhang, Kaixian Chen and Hong Liu.*.  Synthesis of 4-Aryl-2(5H)-furanones by Gold(I)-Catalyzed Intramolecular Annulation. Adv. Synth. Catal. 2011, 353, 1413-1419.
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7. Diliang Guo, Tao chen, Deju Ye, Jinyi Xu, Hualiang Jiang, Kaixian Chen, Hui Wang,* and Hong Liu.* Cell-permeable Iminocoumarine-based Fluorescent Dyes for Mitochondria. Organic Letters.2011, 13, 2884-2887.
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9. Sinan Wang, Lei Zhang, Xiao Ding, Yu Zhou, Jinfang Wang, Hualiang Jiang, Hong Liu. *Synthesis of 2-Phenylnaphthalenes through Gold-Catalyzed Dimerization via a Highly Selective Carbon Nucleophile Pathway. Journal of Organic Chemistry. 2011, 76, 4514-4521.
10. Yu Zhou, Jian Li, Xun Ji, Wei Zhou, Xu Zhang, Wangke Qian, Hualiang Jiang, and Hong Liu. *  Silver- and Gold-Mediated Domino Transformation:A Strategy for Synthesizing Benzo[e]indolo[1,2-a]pyrrolo/pyrido[2,1-c][1,4]diazepine-3,9-dione. J. Org. Chem. 2011, 76, 1239-1249.
11. Jiang Wang, Daizong Lin, Shengbin Zhou, Xiao Ding, Vadim A. Soloshonok, and Hong Liu. * Asymmetric Synthesis of Sterically and Electronically Demanding Linear ?-Trifluoromethyl Containing Amino Acids via Alkylation of Chiral Equivalents of Nucleophilic Glycine and Alanine. J. Org. Chem.2011, 76, 684-687.
12. Xu Zhang, Yu Zhou, Hengshuai Wang, Diliang Guo, Deju Ye, Yungen Xu, Hualiang Jiang, and Hong Liu.* Silver-catalyzed intramolecular hydroamination of alkynes in aqueous media: efficient and regioselective synthesis for fused benzimidazoles. Green Chemistry. 2011, 13, 397-405.
13. Yu Zhou,Yun Zhai, Jian Li, Deju Ye, Hualiang Jiang and Hong Liu*.  Metal-free Tandem Reaction in Water: An Efficient and Regioselective Synthesis of 3-Hydroxyisoindolin-1-ones. Green Chem. 2010, 12, 1397-1404.
14. Dengyou Zhang, Deju Ye, Enguang Feng, Jinfang Wang, Jianmei Shi, Hualiang Jiang, and Hong Liu*.  Highly α-selective synthesis of sialyl hydantoins by regiospecific domino condensation/O-->N acyl migration/N-sialylation of carbodiimides with peracetylated sialic acid. J. Org. Chem. 2010, 75, 3552-3557.
15. Lei Zhang, Deju Ye, Yu Zhou, Guannan Liu, Enguang Feng, Hualiang Jiang, and Hong Liu*.  Regioselective Synthesis of 3-Benzazepinones and Unexpected 5-Bromo-3-benzazepinones. J.Org.Chem. 2010, 75, 3671-3677.
16. Diliang Guo, He Huang, Yu Zhou, Jinyi Xu, Hualiang Jiang, Kaixian Chen, and Hong Liu*  Ligand-free Iron/Copper Cocatalyzed N-Arylations of Aryl Halides with Amines under Microwave Irradiation. Green Chem. 2010, 12, 276-281.
17. He Huang, Qin Chen，Xin Ku, Linghua Meng*, Liping Lin, Xiang Wang, Caihua Zhu, Yi Wang, Zhi Chen, Ming Li, Hualiang Jiang, Kaixian Chen, Jian Ding , Hong Liu.* A series of α-heterocyclic carboxaldehyde thiosemicarbazones inhibit topoisomerase IIα catalytic activity. Journal of Medicinal Chemistry 2010, 53, 3048-3064.
18. Haifeng Sun, He Huang, Dengyou Zhang, Enguang Feng, Wangke Qian, Lei Zhang, Kaixian Chen, and Hong Liu.* Synthesis of 4-Aryl-2(5H)-furanones by Au (Ι)-Catalyzed Intramolecular Annulation. Advanced Synthesis & Catalysis. 2010, 353, 1413-1419.
19. Jiang Wang, Lei Zhang, Hualiang Jiang, Hong Liu.*Most Efficient Routes for the Synthesis of α,β-Diamino Acid-Derived Compounds. Current Pharmaceutical Design, 2010, 16, 1252-1259.
20. Xiaodong Zhang, Deju Ye, Haifeng Sun, Diliang Guo, Jiang Wang, He Huang, Xu Zhang, Hualiang Jiang and Hong Liu.* Microwave-assisted synthesis of quinazolinone derivatives by efficient and rapid iron-catalyzed cyclization in water. Green Chem. 2009, 11, 1881–1888.
21. Diliang Guo, He Huang, Jinyi Xu, Hualiang Jiang, and Hong Liu.* Efficient Iron-catalyzedN-Arylation of Aryl Halides with Amines. Organic Letters. 2008, 10, 4513-4516. (highlighted by SYNFACTS, 2009, 1, 0076)
22. He Huang, Hualiang Jiang, Kaixian Chen and Hong Liu.* Efficient Iron/Copper Cocatalyzed Alkynylation of Aryl Iodides with Terminal Alkynes. Journal of Organic Chemistry 2008, 73, 9601-9604.(highlighted by SYNFACTS, 2009, 3, 0308 and Organic Chemistry Portal)
23. Zhaoguang Li,Hongbin Sun, Hualiang Jiang, Hong Liu*. Copper-catalyzed Intramolecular Cyclization toN-substituted 1,3-Dihydrobenzimidazol-2-ones. Organic Letters. 2008, 10, 3263-3266.
24. He Huang, Hualiang Jiang, Kaixian Chen, and Hong Liu,*. Rapid and Efficient Pd-Catalyzed Sonogashira Coupling of Aryl Chlorides. Journal of Organic Chemistry 2008, 73, 6037-6040.(highlighted by SYNFACTS, 2008, 11, 1201 and Organic Chemistry Portal).

课题组具有国际一流水平的实验设备，包括LC-MS-MS(液质联用仪)，制备液相，低温微波反应仪，ISCO分离纯化设备等。

实验室照片1		实验室照片2
集体照		液质联用仪
微波反应仪		ISCO快速分离纯化系统