NMR-based platform for fragment-based lead discovery used in screening BRD4-targeted compounds.

USP28 and USP25 are downregulated by Vismodegib in vitro and in colorectal cancer cell lines.

Small-Molecule Targeting of E3 Ligase Adaptor SPOP in Kidney Cancer.

Allosteric Regulation of Hsp90alpha's Activity by Small Molecules Targeting the Middle Domain of the Chaperone.

Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia.

The N-terminal ubiquitin-binding region of ubiquitin-specific protease 28 modulates its deubiquitination function: NMR structural and mechanistic insights.

Pharmacokinetics-Based Identification of Potential Therapeutic Phthalides from XueBiJing, a Chinese Herbal Injection Used in Sepsis Management.

Fragment-based drug discovery of triazole inhibitors to block PDEdelta-RAS protein-protein interaction.

Structural and Functional Investigations of the N-Terminal Ubiquitin Binding Region of Usp25.

Yang, Y.; Shi, L.; Ding, Y.; Shi, Y.; Hu, H. Y.; Wen, Y.; Zhang, N. Structural and Functional Investigations of the N-Terminal Ubiquitin Binding Region of Usp25. Biophysical journal 2017,112,2099-2108

A complex structure of arrestin-2 bound to a G protein-coupled receptor[J].

Interplay between Alzheimer's disease and global glucose metabolism revealed by the metabolic profile alterations of pancreatic tissue and serum in APP/PS1 transgenic mice.